A Human Torque Teno Virus Encodes a MicroRNA That Inhibits Interferon Signaling

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A Human Torque Teno Virus Encodes a MicroRNA That Inhibits Interferon Signaling

Torque teno viruses (TTVs) are a group of viruses with small, circular DNA genomes. Members of this family are thought to ubiquitously infect humans, although causal disease associations are currently lacking. At present, there is no understanding of how infection with this diverse group of viruses is so prevalent. Using a combined computational and synthetic approach, we predict and identify m...

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Torque teno virus: a ubiquitous virus☆

caid et al. showed that the TTV encodes a miRNA in vivo that orque teno virus (TTV) is a non-enveloped human DNA virus solated by Nishizawa et al. in 1997.1 TTV, recently classified s the Alphatorquevirus genus within the Anelloviridae family by he International Committee on Taxonomy of Viruses (ICTV), as the first human virus with a single-stranded circular DNA enome to be identified.2 Thus fa...

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TTV has been recently identified as a causative agent of non-A to non-G hepatitis. However, the exact role of this virus in the pathogenesis of chronic liver disease (CLD) and the development of hepatocellular carcinoma (HCC) remain controversial. To clarify these issues, the prevalence of this virus and its impact on the severity of liver disease and development of HCC among Egyptian patients ...

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Torque teno virus is a human non-enveloped single- stranded circular DNA virus with icosahedral symmetry

Torque teno virus is a human non-enveloped singlestranded circular DNA virus with icosahedral symmetry and a particle size of approximately 30 nm. TTV was first characterised as a blood-borne virus and was initially referred to as transfusion-transmitted virus (Nishizawa et al. 1997). Its negative-sense genome is 3.6-3.9 kb in size (Mushahwar et al. 1999). Recently, it was renamed Torque teno v...

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ژورنال

عنوان ژورنال: PLoS Pathogens

سال: 2013

ISSN: 1553-7374

DOI: 10.1371/journal.ppat.1003818